Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Diana Finzi, Joel N. Combination therapy for HIV-1 infection can reduce plasma virus to Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence Diana Finzi, Joel Blankson, +14 authors Robert F. Siliciano; Published in. Due to the importance of the latent reservoir in maintaining infection despite .. the long-term persistence of latent virus in HIV-infected individuals Finzi et al.

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Sequencing was performed on viral isolates that represent distinct biological clones obtained with a limiting dilution culture technique. Perelson AS, et al. Citations Publications citing this paper. Dashes represent amino acids that are unchanged from the reference sequence HXB2R.

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.

However, as shown below, the frequency of latently infected cells remains above 0. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Mofenson LM, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.

A stable latent reservoir for HIV-1 in resting CD4+ T lymphocytes in infected children

This child was treated with nonsuppressive antiretroviral regimens consisting of zidovudine, lamivudine, fnizi, and zalcitabine for 3. A particularly dramatic illustration of the stability of the latent reservoir is provided by the case of the child who has had the longest duration 37 months of suppression of viral replication with HAART patient 8.

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Three additional children patients 2, 8, and 12who at entry had been receiving HAART for 4, 16, and 8 months, respectively, and who had sustained suppression of viral replication to undetectable levels, fibzi also followed longitudinally for 17—21 months.

Virus isolated from the latent reservoir at 19 and 21 months showed multiple mutations conferring resistance to zidovudine. Link to citation list in Scopus.

The reverse transcriptase codon 69 flnzi is observed in nucleoside reverse transcriptase inhibitor-experienced HIVinfected individuals, including those without prior or concurrent zidovudine therapy.

Chun TW, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. In this child, none of the 4 HIV-1 isolates cultured after 30 months of suppressive therapy with ritonavir and stavudine had genotypic substitutions in the protease gene that confer resistance to ritonavir. Montaner The Journal latenh infectious diseases CrandallDavid Posada Infection, genetics and evolution: N Engl J Med.

Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, in each of 7 children who had suppression of viral replication to undetectable levels for 1—3 years on HAART, latent replication-competent HIV-1 persisted with little decay, owing to a stable reservoir of infected cells in the postintegration stage of latency.


Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.

dinzi The success of combination therapy for the treatment of HIV-1 infection has resulted in a focus on sources of persistent HIV-1 in treated individuals. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Correlation of virus load in plasma and lymph node tissue in human immunodeficiency virus infection. Replication-competent HIV-1 was recovered from all 18 children from whom sufficient cells were obtained.

Analysis of the viral isolates cultured from this compartment in a group of children who were pretreated with nonsuppressive antiretroviral regimens showed the persistence, for up to 2 years, of drug-resistant substitutions selected by previous nonsuppressive antiretroviral therapies.

Children with perinatally acquired HIV-1 infection were eligible. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection.

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A family of insertion mutations indection codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Finzi D, et al. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children. Viral dynamics in HIV-1 infection.