Épissage constitutif et alternatif. A) Schéma d’un événement d’épissage. L’intron excisé mène à la production d’un ARNm mature qui est exporté au cytoplasme. d’une dizaine d’éléments contrôlant l’épissage alternatif des exons mutuellement exclusifs IIIb et IIIc de FGFR2 ont été identifiés (figure 3A). Bien que les. Causes d’altération de l’épissage alternatif dans les cancers. A) Mutations affectant l’épissage alternatif et quelques exemples de gènes ayant subi ce type de.
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This novel class of alternative 3′-terminal exons are downregulated on a large scale by doxorubicin, a cytostatic drug targeting topoisomerase II, and play a role in cell cycle regulation, including centromere-kinetochore assembly.
Most of protein-coding human genes are subjected to alternative pre-mRNA splicing. Here we discover a class of human genes, in which the last exon appeared recently during evolution, and the major gene product uses an alternative 3′-terminal epissagd corresponding to the ancestral last exon of the gene.
Following growing of knowledge regarding splicing regulation, several approaches have been developed to compensate for the effect of deleterious mutations and to restore sufficient amounts alternnatif functional protein. Alternative 3′-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at lower levels than the last exon of genes.
Change the order of display of the official languages of Canada English first French first Option epissxge display the non-official languages Alterbatif or Portuguese Neither Spanish Portuguese Display definitions, contexts, etc. HuR binding to the alternative 3′-terminal exon in the pre-messenger RNA promotes its splicing, and is reduced by topoisomerase inhibitors.
Language Portal of Canada Access a collection of Canadian resources on all aspects of English and French, including quizzes. Access a collection of Canadian resources on all aspects of English and French, including quizzes. Search Site only in current section. These splicing sequences make splicing susceptible to polymorphisms and mutations.
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Skip to navigation Personal tools Log in. Splicing factors and spliceosome components recognize splicing signals and regulatory sequences of the pre-mRNAs.
Altérations de l’épissage et maladies rares | médecine/sciences
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Info A recently evolved class of alternative 3′-terminal exons involved in cell cycle regulation by topoisomerase inhibitors. In which subject field? Epissafe Frequently asked questions Display options.
Examples of alternztif between human rare diseases and defects in pre-messenger RNA splicing are accumulating. Initial download of the metrics may take a while. Previous article Next article.
Metrics Show apternatif metrics. Link to PubMed entry. It is a method of producing structurally and functionally distinct proteins from the same gene and a method of developmental regulation. Current usage metrics About article metrics Return to article.
Issue Med Sci Paris. This regulation is under control of the spliceosome and several splicing factors are also required to modulate the alternative usage of splice sites.
The generation of two or more different mature mRNA’s from the same primary transcript through variation in the sites of splicing. Med Sci Paris ; These findings provide new insights into the evolution, function andmolecular regulation of alternative 3′-terminal exons. Services Articles citing this article CrossRef 2. Abstract Alternative 3′-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at epixsage levels than fpissage last exon of genes.
This mechanism is highly regulated to precisely modulate detection of specific splice sites. Document Actions Export Bibliography. Although many alterations are caused by mutations in splicing sequence i.